RNAIII-inhibiting peptide(TFA)
CAS No.
RNAIII-inhibiting peptide(TFA) ( )
Catalog No. M30111 CAS No.
RNAIII-inhibiting peptide(TFA) is a potent inhibitor of Staphylococcus aureus, effective in the diseases such as cellulitis, keratitis, septic arthritis, osteomylitis and mastitis.RNAIII-inhibiting peptide(TFA) is a potent inhibitor of Staphylococcus aureus.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
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Biological Information
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Product NameRNAIII-inhibiting peptide(TFA)
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NoteResearch use only, not for human use.
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Brief DescriptionRNAIII-inhibiting peptide(TFA) is a potent inhibitor of Staphylococcus aureus, effective in the diseases such as cellulitis, keratitis, septic arthritis, osteomylitis and mastitis.RNAIII-inhibiting peptide(TFA) is a potent inhibitor of Staphylococcus aureus.
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DescriptionRNAIII-inhibiting peptide(TFA) is a potent inhibitor of Staphylococcus aureus, effective in the diseases such as cellulitis, keratitis, septic arthritis, osteomylitis and mastitis.RNAIII-inhibiting peptide(TFA) is a potent inhibitor of Staphylococcus aureus. (In Vitro):RNAIII-inhibiting peptide(TFA) is a potent inhibitor of Staphylococcus aureus. RNAIII-inhibiting peptide (RIP) inhibits the synthesis of both RNAII and RNAIII, while RAP activates in wild type S. aureus cells. RNAIII-inhibiting peptide (5 μg/106 cells) potently reduces bacterial cell adhesion to HEp2 cells in the absence of serum, but with slight overall reduction the presence of serum. RNAIII-inhibiting peptide inhibits while RAP induces the phosphorylation of TRAP.(In Vivo):RNAIII-inhibiting peptide (20 mg/kg, i.v.) decreases lethality in mice challenged with S. aureus ATCC 25923, with the lethality rate of 70%, and when combined with cefazolin, imipenem, vancomycin, the rates are 20%, 15% and 10%. RNAIII-inhibiting peptide (20 mg/kg, i.v.) also causes decreased lethality in mice challenged with S. aureus Smith, with the lethality rate of 75%, and the lethality rate decreases to 30%, 10% and 10% when combined with cefazolin, imipenem, vancomycin.
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Synonyms
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PathwayOthers
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TargetOther Targets
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RecptorStaphylococcus aureus
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Research Area——
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Indication——
Chemical Information
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CAS Number--
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Formula Weight1027
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Molecular FormulaC47H57F3N10O13
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Purity>98% (HPLC)
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SolubilityDMSO : ≥ 150 mg/mL (146.06 mM)
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SMILES——
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Chemical Name
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
Gov Y, et al. RNAIII inhibiting peptide (RIP), a global inhibitor of Staphylococcus aureus pathogenesis: structure and function analysis. Peptides. 2001 Oct;22(10):1609-20.
molnova catalog
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