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RNAIII-inhibiting peptide(TFA)

CAS No.

RNAIII-inhibiting peptide(TFA) ( )

Catalog No. M30111 CAS No.

RNAIII-inhibiting peptide(TFA) is a potent inhibitor of Staphylococcus aureus, effective in the diseases such as cellulitis, keratitis, septic arthritis, osteomylitis and mastitis.RNAIII-inhibiting peptide(TFA) is a potent inhibitor of Staphylococcus aureus.

Purity : >98% (HPLC)

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Biological Information

  • Product Name
    RNAIII-inhibiting peptide(TFA)
  • Note
    Research use only, not for human use.
  • Brief Description
    RNAIII-inhibiting peptide(TFA) is a potent inhibitor of Staphylococcus aureus, effective in the diseases such as cellulitis, keratitis, septic arthritis, osteomylitis and mastitis.RNAIII-inhibiting peptide(TFA) is a potent inhibitor of Staphylococcus aureus.
  • Description
    RNAIII-inhibiting peptide(TFA) is a potent inhibitor of Staphylococcus aureus, effective in the diseases such as cellulitis, keratitis, septic arthritis, osteomylitis and mastitis.RNAIII-inhibiting peptide(TFA) is a potent inhibitor of Staphylococcus aureus. (In Vitro):RNAIII-inhibiting peptide(TFA) is a potent inhibitor of Staphylococcus aureus. RNAIII-inhibiting peptide (RIP) inhibits the synthesis of both RNAII and RNAIII, while RAP activates in wild type S. aureus cells. RNAIII-inhibiting peptide (5 μg/106 cells) potently reduces bacterial cell adhesion to HEp2 cells in the absence of serum, but with slight overall reduction the presence of serum. RNAIII-inhibiting peptide inhibits while RAP induces the phosphorylation of TRAP.(In Vivo):RNAIII-inhibiting peptide (20 mg/kg, i.v.) decreases lethality in mice challenged with S. aureus ATCC 25923, with the lethality rate of 70%, and when combined with cefazolin, imipenem, vancomycin, the rates are 20%, 15% and 10%. RNAIII-inhibiting peptide (20 mg/kg, i.v.) also causes decreased lethality in mice challenged with S. aureus Smith, with the lethality rate of 75%, and the lethality rate decreases to 30%, 10% and 10% when combined with cefazolin, imipenem, vancomycin.
  • Synonyms
  • Pathway
    Others
  • Target
    Other Targets
  • Recptor
    Staphylococcus aureus
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    --
  • Formula Weight
    1027
  • Molecular Formula
    C47H57F3N10O13
  • Purity
    >98% (HPLC)
  • Solubility
    DMSO : ≥ 150 mg/mL (146.06 mM)
  • SMILES
    ——
  • Chemical Name

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

Gov Y, et al. RNAIII inhibiting peptide (RIP), a global inhibitor of Staphylococcus aureus pathogenesis: structure and function analysis. Peptides. 2001 Oct;22(10):1609-20.
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